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KMID : 0939920160480041274
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대한암학회지
2016 Volume.48 No. 4 p.1274 ~ p.1285
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Is There a Role for Adjuvant Therapy in R0 Resected Gallbladder Cancer?: A Propensity Score-Matched Analysis
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Go Se-Il
Kim Young-Saing
Hwang In-Gyu
Kim Eun-Young
Oh Sung-Yong
Ji Jun-Ho
Song Haa-Na
Park Se-Hoon
Park Joon-Oh
Kang Jung-Hun
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Abstract
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Purpose : The purpose of this study is to assess the role of adjuvant therapy in stage I-III gallbladder cancer (GBC) patients who have undergone R0 resection.
Materials and Methods : Clinical data were collected on 441 consecutive patients who underwent R0 resection for stage I-III GBC. Eligible patients were classified into adjuvant therapy and surveillance only groups. Propensity score matching (PSM) between the two groups was performed, adjusting clinical factors.
Results : In total, 84 and 279 patients treated with adjuvant therapy and followed up with surveillance only, respectively, were included in the analysis. Before PSM, the 5-year relapse-free survival (RFS) rate was lower in the adjuvant therapy group than in the surveillance only group (50.8% vs. 74.8%, p < 0.001), although there was no statistically significant difference in the 5-year overall survival (OS) rate (66.2% vs. 79.5%, p=0.089). After the PSM, baseline characteristics became comparable and there were no differences in the 5-year RFS (50.8% vs. 64.8%, p=0.319) and OS (66.2% vs. 70.4%, p=0.703) rates between the two groups.
Conclusion : The results suggest that fluoropyrimidine-based adjuvant therapy is not indicated in stage I-III GBC patients who have undergone R0 resection.
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KEYWORD
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Gallbladder neoplasms, Adjuvant chemotherapy, Adjuvant chemoradiotherapy, Survival, Propensity score
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